How Are Glass Jacketed Reactors Used In a Lab

Reaction equipment is one of the very important equipment used in the production process of the pharmaceutical manufacturing industry. In recent years, with the rapid development of the pharmaceutical and pharmaceutical machinery industry, the role of the reactor as a kind of pharmaceutical machinery and equipment will become more and more obvious . However, with the gradual expansion of the application of the reactor in the pharmaceutical field, its safety accidents also occur frequently. Therefore, enterprises should pay close attention to various details in the process of producing and using reactors to promote better application of reactors in the pharmaceutical production process.

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What is a glass jacketed reactor?

A glass jacketed reactor is a vessel used to carry out chemical reactions. It’s made of borosilicate glass, a type of glass known for its heat and chemical resistance. The reactor consists of a cylindrical vessel with an opening at the top, an agitator for mixing the contents of the reactor, and a condenser for condensing the vapors generated during the reaction. The glass reactor can be used for high temperature reaction (high temperature can reach 300 ℃), low temperature reaction (low temperature can reach -80 ℃), and can also be evacuated to perform vacuum reaction.

The reactor is also equipped with a jacket around the vessel which is filled with a heat transfer fluid. This jacket design allows efficient heating or cooling of the reaction mixture depending on the requirements of the reaction.

Uses of glass jacketed reactors:

Glass jacketed reactors are used in laboratories for a variety of purposes, including:

Chemical synthesis:

Glass jacketed reactors are commonly used in chemical synthesis because they allow precise control of reaction conditions such as temperature, pressure, and mixing speed. This makes it possible to perform reactions with high efficiency and high yield, which is important for the production of pharmaceuticals, fine chemicals and other products.

Process development:

Glass jacketed reactors are also used in process development, which involves optimizing reaction conditions for maximum efficiency and yield. This process usually involves screening different reaction conditions using small reactors, such as glass-jacketed reactors, before scaling up to larger reactors.

Zoom in on research:

Once the reaction is optimized in a small reactor, it can be scaled up to a larger reactor for commercial production. Glass-jacketed reactors are often used for scale-up studies because they allow precise control of reaction conditions and can be easily modified to accommodate different reactor sizes and configurations.

Pharmaceutical production:

Glass jacketed reactors are widely used in the pharmaceutical industry for the production of active pharmaceutical ingredients (APIs), which are the key ingredients of medicines. These reactors are commonly used for the synthesis of APIs, as well as downstream processes such as purification and crystallization.

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Features of glass jacketed reactor

Borosilicate glass:

Glass jacketed reactors are made of borosilicate glass, which is highly resistant to thermal and chemical stress. This makes the reactor durable, even under harsh reaction conditions.

Jacket design:

Glass jacketed reactors are designed with a jacket surrounding the vessel to efficiently heat or cool the reaction mixture. This jacket design also helps prevent glass containers from cracking due to thermal stress.


Most glass jacketed reactors are equipped with a stirrer to help mix the contents of the reactor and increase the efficiency of the reaction.


The glass jacketed reactor also has a condenser to condense the vapors generated during the reaction. This helps prevent loss of reaction product and allows for more efficient product recovery.

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How are glass jacketed reactors used in a lab?

To react with different media in a glass reactor, first check whether the media corrodes the main material.

Special orders are required for instantaneous reactions that produce a large amount of gas or high-temperature inflammable and explosive chemical reactions, as well as high-pressure, high-temperature or medium containing chloride ions, fluorine ions, etc. that cause serious corrosion to stainless steel.

According to relevant staff, the glass reactor should not exceed 2/3 of the liquid level of the reactor body when the reaction medium is loaded;

The jacket is heated by heat transfer oil. When adding heat transfer oil, be careful not to mix water or other liquids into it, and check the oil level of the heat transfer oil from time to time;

Regularly check the swing of the stirring shaft. If the swing is too large, it means that the bearing or sliding sleeve should be replaced;

Connect the corresponding voltage according to the operating voltage of the controller, single-phase 220V, three-phase 380V, do not reverse the live wire and neutral wire of the controller; do not perform wiring work during power transmission to prevent electric shock!

In order to ensure the normal operation of the controller and the personal safety of the staff, please be sure to ground the wire! The controller is not explosion-proof and should be kept away from flammable and explosive environments;

When the reaction temperature is determined, it is not allowed to change the temperature setting value during the heating process to avoid large overshoot of the temperature.

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Only by using the equipment correctly can the normal operation of the equipment be ensured. At the same time, it is necessary to master the handling of abnormal phenomena and reduce the occurrence of accidents. FBL laboratory instruments strive for survival by quality and development by reputation, and strive to provide advanced production technology, excellent production technology, reliable quality assurance and perfect after-sales service to new and old customers, and wholeheartedly serve major scientific research institutions, Products and good after-sales service are provided for key projects such as drug inspection, chemical industry, metallurgy, petroleum, biochemistry, and food processing.

How Are Glass Jacketed Reactors Used In a Lab

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